{"id":17781,"date":"2026-08-21T13:11:12","date_gmt":"2026-08-21T03:11:12","guid":{"rendered":"https:\/\/geoffreychen.com\/?p=17781"},"modified":"2026-08-21T13:11:13","modified_gmt":"2026-08-21T03:11:13","slug":"mrna-cancer-vaccines-ai-neoantigen-breakthroughs","status":"publish","type":"post","link":"https:\/\/geoffreychen.com\/zh\/mrna-cancer-vaccines-ai-neoantigen-breakthroughs\/","title":{"rendered":"mRNA\u764c\u75c7\u75ab\u82d7\u6b63\u5728\u8de8\u8fc7\u54ea\u9053\u95e8\u69db"},"content":{"rendered":"<\/p>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/public-assets.geoffreychen.com\/wordpress\/articles\/mrna-cancer-vaccines-ai-neoantigen-breakthroughs\/e10746c611acea2c0425e265.jpg?w=1140&#038;ssl=1\" alt=\"mRNA\u764c\u75c7\u75ab\u82d7\u6b63\u5728\u8de8\u8fc7\u54ea\u9053\u95e8\u69db\" loading=\"lazy\"><\/p>\n<p>\u8fc7\u53bb\u51e0\u5e74\uff0cmRNA 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\u7ec6\u80de\u8bb0\u5fc6\u3002<\/p>\n<p>\u76ee\u524d\u8bc1\u636e\u6700\u5f3a\u7684\u9879\u76ee\u6765\u81ea\u9ad8\u98ce\u9669\u9ed1\u8272\u7d20\u7624\u3002\u4e2a\u4f53\u5316\u65b0\u6297\u539f\u7597\u6cd5 intismeran autogene\uff0c\u4e5f\u5c31\u662f\u8fc7\u53bb\u6240\u79f0\u7684 mRNA-4157 \u6216 V940\uff0c\u4f1a\u6839\u636e\u6bcf\u4f4d\u60a3\u8005\u80bf\u7624\u4e2d\u7684\u7a81\u53d8\uff0c\u5236\u4f5c\u4e00\u6bb5\u53ef\u4ee5\u7f16\u7801\u6700\u591a 34 \u4e2a\u65b0\u6297\u539f\u7684 mRNA\u3002\u5b83\u4e0d\u662f\u5355\u72ec\u4f7f\u7528\uff0c\u800c\u662f\u4e0e\u89e3\u9664\u514d\u75ab\u201c\u5239\u8f66\u201d\u7684 PD-1 \u6291\u5236\u5242 pembrolizumab \u8054\u7528\u3002\u5728\u4e00\u9879 157 \u4eba\u53c2\u52a0\u7684\u968f\u673a IIb \u671f\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u5728\u80bf\u7624\u5b8c\u5168\u5207\u9664\u540e\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u6216\u5355\u7528 pembrolizumab\u30022026 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\u7684 KEYNOTE-942 \u4e94\u5e74\u968f\u8bbf <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-26-00835\uff0cNature\" rel=\"nofollow\">https:\/\/ascopubs.org\/doi\/10.1200\/JCO-26-00835\uff0cNature<\/a> \u7684\u80f0\u817a\u764c\u7814\u7a76 <a href=\"https:\/\/doi.org\/10.1038\/s41586-024-08508-4\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41586-024-08508-4<\/a> \u4e0e\u4e09\u9634\u6027\u4e73\u817a\u764c\u7814\u7a76 <a href=\"https:\/\/doi.org\/10.1038\/s41586-025-10004-2\uff0cNature\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41586-025-10004-2\uff0cNature<\/a> Biotechnology \u7684 NeoDisc \u7814\u7a76 <a href=\"https:\/\/doi.org\/10.1038\/s41587-024-02420-y\uff0c\u4ee5\u53ca\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41587-024-02420-y\uff0c\u4ee5\u53ca<\/a> ClinicalTrials.gov \u7684 INTerpath-001 <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05933577\" rel=\"nofollow\">https:\/\/clinicaltrials.gov\/study\/NCT05933577<\/a> \u548c\u80f0\u817a\u764c\u968f\u673a II 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